Michael Friger

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BACKGROUND Statins have anti-inflammatory properties that are independent of their lipid-lowering abilities. We hypothesized that statin therapy before the onset of an acute bacterial infection may have a protective effect against severe sepsis. The aim of this study was to determine whether patients treated with statins develop severe sepsis less(More)
Environmental factors such as ambient air pollution have been associated with congenital heart defects. The aim of this study was to investigate the association between gestational exposure to air pollution and the risk of congenital heart defects. We conducted a registry-based cohort study with a total of 135,527 live- and still-births in the Tel-Aviv(More)
BACKGROUND & AIMS Economic analysis in chronic diseases is a prerequisite for planning a proper distribution of health care resources. We aimed to determine the cost of inflammatory bowel disease, a lifetime illness with considerable morbidity. METHODS We studied 1321 patients from an inception cohort in 8 European countries and Israel over 10 years. Data(More)
OBJECTIVE The objective of this study was to evaluate the associations between proximity to green spaces and surrounding greenness and pregnancy outcomes, such as birth weight, low birth weight (LBW), very LBW (VLBW), gestational age, preterm deliveries (PTD) and very PTD (VPTD). METHODS This study was based on 39,132 singleton live births from a registry(More)
BACKGROUND Head lice move easily from head to head. The lack of safe, effective repellents leads to reinfestation. OBJECTIVES To test the efficacy of a slow-release citronella formulation as a repellent against the head louse. METHODS During 4 months in 2003 a randomized, placebo-controlled double-blind clinical study was conducted in four elementary(More)
OBJECTIVE To evaluate neurocognitive functions of children with obstructive sleep apnea syndrome (OSAS), before and after adenotonsillectomy, compared with healthy controls. DESIGN Prospective study. PATIENTS AND METHODS Thirty-nine children with OSAS aged 5 to 9 years (mean age, 6.8 +/- 0.2 years) and 20 healthy children (mean age, 7.4 +/- 1.4 years)(More)
BACKGROUND The aim of this study was to assess effects of natural and artificial seasonality on reproduction in a large cohort of Muslim and Jewish women, living in the same geographic area. METHODS Population included all births between January 1988 and December 2005 (6613 daily records of 200 009 births) at the Soroka University Medical Center (southern(More)
STUDY QUESTION Does maternal exposure during pregnancy to higher ambient temperature increase the risk of congenital heart defects (CHDs)? SUMMARY ANSWER Significant associations were found between maternal exposure during pregnancy to higher ambient temperature and CHDs risk especially during the cold season. WHAT IS KNOWN ALREADY From rodents to(More)
INTRODUCTION Many mechanically ventilated elderly patients in Israel are treated outside of intensive care units (ICUs). The decision as to whether these patients should be treated in ICUs is reached without clear guidelines. We therefore conducted a study with the aim of identifying triage criteria and factors associated with in-hospital mortality in this(More)
BACKGROUND No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe. METHODS The EpiCom cohort is a prospective population-based inception cohort(More)