Michael Friedrich

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We present OKEANOS, a distributed service-based agent framework implemented in Java, in which agents can act autonomously and make use of stationary services. Each agent's behaviour can be controlled individually by a rule-based knowledge component, and cooperation between agents is supported through the exchange of messages at common meeting points (agent(More)
  • Hicham Majd, Saja S Scherer, Stellar Boo, Silvio Ramondetti, Elizabeth Cambridge, Wassim Raffoul +5 others
  • 2015
Over the past decade, various implantable devices have been developed to treat diseases that were previously difficult to manage such diabetes, chronic pain, and neurodegenerative disorders. However, translation of these novel technologies into clinical practice is often difficult because fibrotic encapsulation and/or rejection impairs device function after(More)
The aim of the present study was the validation of the Acquired Capability for Suicide Scale-Fearlessness about Death (ACSS-FAD) in a large population sample to further establish its reliability and validity, and to provide norm values. We assessed the ACSS-FAD, measures of depression, history of suicidal behavior, and anxiety in a representative sample of(More)
We identified the dsRNA binding protein RbdB as an essential component in miRNA processing in Dictyostelium discoideum. RbdB is a nuclear protein that accumulates, together with Dicer B, in nucleolar foci reminiscent of plant dicing bodies. Disruption of rbdB results in loss of miRNAs and accumulation of primary miRNAs. The phenotype can be rescued by(More)
The Greenland Stadial 1 (GS-1; ~12.9 to 11.65 kyr cal BP) was a period of North Atlantic cooling, thought to have been initiated by North America fresh water runoff that caused a sustained reduction of North Atlantic Meridional Overturning Circulation (AMOC), resulting in an antiphase temperature response between the hemispheres (the 'bipolar seesaw'). Here(More)
CHARACTERISTICS OF DIRS-1 MEDIATED KNOCK-DOWNS We have previously shown that the most abundant Dictyostelium discoideum retroelement DIRS-1 is suppressed by RNAi mechanisms. Here we provide evidence that both inverted terminal repeats have strong promoter activity and that bidirectional expression apparently generates a substrate for Dicer. A cassette(More)
OBJECTIVE Previous studies have established an association between number of traumatic experiences and alexithymia. The present study examines this relationship in a large-scale representative sample of the German general population (N=2,507) and explores the potential mediating effects of posttraumatic symptomatology, particularly avoidance/numbing. (More)