Michael Fielding

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Arabinoxylan is a major dietary fiber component of many cereals. Its physiological effects in the colon are largely unknown. This study examined the effects of an arabinoxylan-rich fiber (AX) extracted from a by-product of wheat flour processing in the rat colon compared with well-characterized soluble/rapidly fermentable and insoluble/slowly fermentable(More)
The purpose of this study was to examine the bleeding patterns of 234 Norplant users during 5 years of use and to identify the bleeding patterns of users who conceived. During the first year of use, 26.6% of users had regular bleeding cycles, 66.3% had irregular cycles, and 7.1% were amenorrheic. By the fifth year of use, 62.5% of users had regular cycles,(More)
Approximately one third of the water supplies in the United Kingdom are derived from lowland rivers receiving industrial and domestic effluent and in some cases the level of indirect re-use may be high. Research, funded by the Department of the Environment, is being undertaken to identify any potentially hazardous organic compounds that may be present in(More)
Sensitization to chemicals resulting in an allergy is an important health issue. The current gold-standard method for identification and characterization of skin-sensitizing chemicals was the mouse local lymph node assay (LLNA). However, for a number of reasons there has been an increasing imperative to develop alternative approaches to hazard(More)
The views expressed in this report are the authors' and do not necessarily reflect those of the Department for Education and Skills. 2.1 Relationships and trust 8 2.11 Prior relationships 8 2.12 Trusting relationships 10 2.13 Relationships and tacit knowledge 11 2.14 It matters who it is: 'The person connection is significant' 12 2.2 Teacher and(More)
The identification of organic chemicals in drinking water and their assessment in terms of potential hazardous effects are two very different but closely associated tasks. In relation to both continuous low-level background contamination and specific, often high-level, contamination due to pollution incidents, the identification of contaminants is a(More)
PURPOSE A free-living animal model with ready and repetitive access to selected regions of the large bowel and with minimally altered bowel anatomy and physiology would facilitate the in vivo study of luminal factors on the colonic mucosa in a steady-state environment. This study describes a novel model of large-bowel intubation in the rat. METHOD Four(More)