Michael Ferris

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Disseminated candidiasis is the third leading nosocomial blood stream infection in the United States and is often fatal. We previously showed that disseminated candidiasis was preventable in normal mice by immunization with either a glycopeptide or a peptide synthetic vaccine, both of which were Candida albicans cell wall derived. A weakness of these(More)
Designing yacht rigs using empirical rules of thumb and large margins of safety can result in rigs that are substantially heavier than they need to be. We describe a suite of mathematical programming models for optimizing the dimensions and minimum scantlings of carbon-fibre rigs. By using mixed complementarity models the finite-element analysis of the rig(More)
The STEP Entity Control System for Concurrent Engineering (SECS/CE) is an archive and version control system that facilitates concurrent engineering by allowing engineers to merge concurrent changes, find conflicts between concurrent changes, ask questions about the contents of changes and designs, and resolve conflicts between design versions produced by(More)
We investigate a new class of congestion games, called Totally Unimodular (TU) Congestion Games, where the players' strategies are binary vectors inside polyhedra defined by totally unimodular constraint matrices. Network congestion games belong to this class. In the symmetric case, when all players have the same strategy set, we design an algorithm that(More)
In simulation-based optimization, we seek the optimal parameter settings that minimize or maximize certain performance measures of the simulation system. In this paper, we use a two-phase approach to calibrate simulation parameters using classification tools. This classification-based method is used in Phase I to facilitate the global search process and it(More)
Systematic, genome-wide loss-of-function experiments can be used to identify host factors that directly or indirectly facilitate or inhibit the replication of a virus in a host cell. We present an approach that combines an integer linear program and a diffusion kernel method to infer the pathways through which those host factors modulate viral replication.(More)
In a recent paper Elvin and Leung [1] demonstrated the advantages of a new fast boundary element algorithm for solving closed crack problems. This algorithm uses the Displacement Discontinuity Method (DDM) and subdivides the problem into two sub-problems, one for the outer boundaries of the structure and one for the crack. In common with most methods for(More)
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