Michael Ferguson

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Sankoff and Ferretti (1996) introduced several models of the evolution of chromosome size by reciprocal translocations, where for simplicity they ignored the existence of centromeres. However, when they compared the models to data on six organisms they found that their short chromosomes were too short, and their long chromosomes were too long. Here, we(More)
In this paper, we present an investigation into the use of cue phrases as a basis for dialogue act classification. We define what we mean by cue phrases, and describe how we extract them from a manually labelled corpus of dialogue. We describe one method of evaluating the usefulness of such cue phrases, by applying them directly as a classifier to unseen(More)
The Sabin type 1 vaccine strain of poliovirus is probably the safest and most successful live-attenuated vaccine virus used in humans. Its widespread use since the early 1960s has contributed significantly to the virtual eradication of poliomyelitis in developed countries. We have reported previously the construction of an intertypic antigen chimaera of(More)
Polioviruses occur as three distinct serotypes, 1, 2 and 3, and are composed of a single-stranded positive-sense RNA genome of approximately 7,450 nucleotides enclosed in an icosahedral particle of diameter 27 nm. The three-dimensional crystallographic structure of poliovirus type 1 has been determined at 2.9 A resolution, providing a detailed knowledge of(More)
A baculovirus expression vector (AcLeon) derived from Autographa californica nuclear polyhedrosis virus (AcNPV) was prepared containing the complete 6.6 kb coding region of the P3/Leon/37 strain of poliovirus type 3 placed under the control of the AcNPV polyhedrin promoter. The recombinant virus was used to infect Spodoptera frugiperda insect cells. As(More)
We have determined a major antigenic site for virus neutralization on the capsid protein VP1 of poliovirus type 3. Antigenic mutant viruses selected for resistance to individual monoclonal antibodies had point mutations concentrated in a region 277-294 bases downstream from the start of the region of viral RNA coding for VP1. These findings provide the(More)
non-progress cycles (Hol92]) are both incompatible with partial order reduction , such as proposed in Peled94, HP94]. We h a ve discussed a mod-iication of one of the two algorithms that secures compatibility with reduction methods, and that suuces to solve b o t h s e a r c h problems eeciently and uniformly. Acknowledgement: The authors are most grateful(More)
He holds a Ph.D. in cultural anthropology from the University of Michigan, where he specialized in Latin American culture and carried out extensive fieldwork in Peru. His turn into microfinance came after years on a conventional academic track. Sebstad, who also provided extensive input on implementation and comments on reporting. Additional thanks to Kate(More)