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Plasmodium vivax in southern Mexico exhibits different infectivities to 2 local mosquito vectors, Anopheles pseudopunctipennis and Anopheles albimanus. Previous work has tied these differences in mosquito infectivity to variation in the central repeat motif of the malaria parasite's circumsporozoite (csp) gene, but subsequent studies have questioned this(More)
OBJECTIVES To assess the safety and immunogenicity of two vaccines, MSP1(42)-FVO/Alhydrogel and MSP1(42)-3D7/Alhydrogel, targeting blood-stage Plasmodium falciparum parasites. DESIGN A Phase 1 open-label, dose-escalating study. SETTING Quintiles Phase 1 Services, Lenexa, Kansas between July 2004 and November 2005. PARTICIPANTS Sixty healthy(More)
  • Ehud Inbar, Natalia S. Akopyants, Melanie Charmoy, Audrey Romano, Phillip Lawyer, Dia-Eldin A. Elnaiem +9 others
  • 2013
Invertebrate stages of Leishmania are capable of genetic exchange during their extracellular growth and development in the sand fly vector. Here we explore two variables: the ability of diverse L. major strains from across its natural range to undergo mating in pairwise tests; and the timing of the appearance of hybrids and their developmental stage(More)
INTRODUCTION Accurate knowledge of O(6)-methylguanine methyltransferase (MGMT) gene promoter subtype in patients with glioblastoma (GBM) is important for treatment. However, this test is not always available. Pre-operative diffusion MRI (dMRI) can be used to probe tumour biology using the apparent diffusion coefficient (ADC); however, its ability to act as(More)
The marine biodiversity of Gabon, West Africa has not been well studied and is largely unknown. Our examination of marine communities associated with oil platforms in Gabon is the first scientific investigation of these structures and highlights the unique ecosystems associated with them. A number of species previously unknown to Gabonese waters were(More)
Nicotine discontinuation produces behaviors in rats that are congruent with anhedonia, and these symptoms may be related to the devaluation of non-nicotine reinforcers. Four separate experiments were performed to explore the parameters surrounding nicotine-induced reinforcer devaluation. In Experiments 1 and 2, nicotine (0.1 or 0.3 mg/kg) or 0.3 mg/kg(More)
Tumors are typically analyzed as a single unit, despite their biologically heterogeneous nature. This limits correlations that can be drawn between regional variation and treatment outcome. Furthermore, despite the availability of high resolution 3-D medical imaging techniques, local outcomes, (e.g., tumor growth), are not easily measured. This paper(More)
Track-Weighted Imaging (TWI), where voxel intensity is based on image metrics encoded along streamline trajectories, provides a mechanism to study white matter disease. However, with generalised streamline weighting, it is difficult to localise the precise anatomical source and spread of injury or neuropathology. This limitation can be overcome by(More)