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BACKGROUND Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder originating from exposure to bovine-spongiform-encephalopathy-like prions. Prion infections are associated with long and clinically silent incubations. The number of asymptomatic individuals with vCJD prion infection is unknown, posing risk to others via blood(More)
Currently, no treatment can prevent the cognitive and motor decline associated with widespread neurodegeneration in prion disease. However, we previously showed that targeting endogenous neuronal prion protein (PrP(C)) (the precursor of its disease-associated isoform, PrP(Sc)) in mice with early prion infection reversed spongiform change and prevented(More)
Mutations in the charged multivesicular body protein 2B (CHMP2B) gene cause frontotemporal lobar degeneration. The mutations lead to C-terminal truncation of the CHMP2B protein. We generated Chmp2b knockout mice and transgenic mice expressing either wild-type or C-terminally truncated mutant CHMP2B. The transgenic CHMP2B mutant mice have decreased survival(More)
Intraperitoneal administration of ICSM18 and 35, monoclonal antibodies against prion protein (PrP), has been shown to significantly delay the onset of prion disease in mice, and humanized versions are candidate therapeutics for prion and Alzheimer's diseases. However, a previous report of severe and widespread apoptosis after intracerebral injection of(More)
SECURE BIOMETRIC SYSTEMS By Umut Uludag Traditional personal authentication systems that are based on knowledge (e.g., password) or physical tokens (e.g., ID card) are not able to meet strict security performance requirements of a number of modern applications. These applications generally make use of computer networks (e.g., Internet), affect a large(More)
Nontypeable Haemophilus influenzae (NTHi) is a prevalent bacterium found in a variety of chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung inflammation is not well defined. In this study we examined the effect of NTHi on two important lung inflammatory processes 1), oxidative stress and 2), protease expression.(More)
Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody(More)
This literature review attempts to provide a brief overview of some of the most common image segmentation techniques. It discusses Edge detection technique, Thresholding technique, Region growing based technique, Watershed technique, Compression based method, Histogram based segmentation and Graph partitioning method. With the growing research on image(More)
Much research has been devoted to the study of exclusively distance-learning paradigms for teaching various technological subjects, yet many students have not been satisfied with existing distance learning methodologies. This paper addresses a new approach called the cyber classroom, which combines the best practices of distance learning with traditional "(More)