Michael F. Waxman

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Suppressive petite mutants isolated from a strain possessing a nuclear gene which controls the transmission of mitochondria are highly suppressive in all crosses to grande strains. Suppressive petite mutants derived from other strains are also highly suppressive in all crosses except when crossed to strains carrying the nuclear control gene; in these(More)
Phenotypic “revertants” of a drug resistant strain of Saccharomyces cerevisiae were induced by mutgenesis with manganese. Several of these drug sensitive mutants have been shown to result from mutations in the nuclear genome that cause phenotypic modification (suppression) of the mitochondrially-determined drug resistant genotype. Four mutants carrying a(More)
Transmission of mitochondrial factors was studied in zygote clones, random diploids, and zygote cell lineages. An asymmetrical distribution of both parental and recombinant classes was consistently seen. Genetic analysis indicated that a nuclear factor was controlling this pattern. Treatment of young zygotes with either cycloheximide or thiolutin for 90(More)
Crosses were made between strains carrying a nuclear control factor (NC) and strains classified with respect to their omega allele (ω+ or ω-). The characteristic asymmetrical transmission was always observed (as was seen) in crosses not involving the ω factor. The analysis of functional recombinants in a cross involving an NC factor has indicated that the(More)
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