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We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative(More)
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population(More)
A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA generated from approximately 0.3 g of bone. Analysis of the assembled sequence unequivocally establishes that the Neandertal mtDNA falls outside the variation of extant human mtDNAs, and allows(More)
Recent advances in high-thoughput DNA sequencing have made genome-scale analyses of genomes of extinct organisms possible. With these new opportunities come new difficulties in assessing the authenticity of the DNA sequences retrieved. We discuss how these difficulties can be addressed, particularly with regard to analyses of the Neandertal genome. We argue(More)
Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the(More)
Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: Accession codes All sequence data have been submitted to the European Nucleotide Archive (ENA) and are available under the following accessions: Altai Neandertal: ERP002097,(More)
The search for distant homologs has become an import issue in genome annotation. A particular difficulty is posed by divergent homologs that have lost recognizable sequence similarity. This same problem also arises in the recognition of novel members of large classes of RNAs such as snoRNAs or microRNAs that consist of families unrelated by common descent.(More)
  • Francesco Righetti, Aaron M Nuss, Christian Twittenhoff, Sascha Beele, Kristina Urban, Sebastian Will +35 others
  • 2015
[2] Sebastian Will 1 and Hosna Jabbari. Sparse RNA folding revisited: space-efficient minimum free energy structure prediction. quadratic time simultaneous alignment and folding of RNAs without sequence-based heuristics. Local exact pattern matching for non-fixed RNA structures. Structure-based whole genome realignment reveals many novel non-coding RNAs.(More)
This peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in Algorithms for Molecular Biology are listed in PubMed and archived at PubMed Central. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract(More)
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