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The perception of pain is initiated by the transduction of noxious stimuli through specialized ion channels and receptors expressed by primary nociceptive neurons. The molecular mechanisms that… Continue Reading
BackgroundThe functional state of glial cells, like astrocytes and microglia, critically modulates the course of neuroinflammatory and neurodegenerative diseases and can have both detrimental and… Continue Reading
Recent evidence suggests a pivotal role of the proinflammatory cytokine interleukin - 17A (IL-17) in demyelinating autoimmune diseases of the central nervous system (CNS) such as multiple sclerosis… Continue Reading
resident microglia (MG) and peripheral immune cells infiltrating into the region surrounding the infarct core and leading to secondary neurodegeneration. Current clinical therapies using thrombolytic… Continue Reading