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A sensitive immunohistochemical technique was used to demonstrate zinc metallothionein in rat and human liver and ileum. In the liver, immunoreactivity was observed within the hepatocyte nucleus and cytoplasm, in sinusoids, canaliculi and blood vessels. In the ileum, immunoreactivity was present in the enterocyte nucleus and cytoplasm, and in the lamina(More)
The number of apoptotic bodies found in the small intestine of control non-fasted rats was low. Apoptotic bodies were found in the crypt region of zinc-deficient rats and were present in very large numbers in half the animals examined. Increased numbers of apoptotic bodies were found in the crypt and fundic regions of fasted rats. The failure of cellular(More)
An ultrastructural study into the origins of the increased number of apoptotic bodies in the small intestinal crypts of zinc deficient rats was carried out. Two strains of rat were used and each strain was sub-divided into three groups; zinc deficient, pair-fed controls and ad libitum controls. All three groups of one strain were heavily infested with(More)
Histochemical methods do not always show a good correlation with analytical measurement of copper content and consequently immunoreactive staining techniques for metallothionein (MT) have recently been employed for the differential diagnosis of copper-associated diseases. This study compares histochemical with immunocytochemical methods for the assessment(More)
The present study examined the extent to which the late gestation rise in fetal plasma cortisol influenced adipose tIssue development in the fetus. The effect of cortisol on the abundance of adipose tIssue mitochondrial proteins on both the inner (i.e. uncoupling protein (UCP)1) and outer (i.e. voltage-dependent anion channel (VDAC)) mitochondrial membrane,(More)
The aim of this study was to contribute to the understanding of the pathogenesis of copper-induced damage and subsequent recovery and tolerance to copper in the copper-loaded rat liver. Male Wistar rats were allocated randomly into groups of four, fed a pelleted diet containing 1500 mg/g copper, and killed at 1, 5, 6, 10, and 15 weeks. Two additional groups(More)
In normal rats changes in the enterocytes that appear to be associated with physiological cell death were found. They were confined to the villous tip and included fragmentation of the microvilli and increased electron density of the cytoplasm with morphological alterations of the organelles. Acute severe zinc deficiency in young rats results in(More)