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Previous studies have identified three brain proteins (40, 65 and 95 kDa, respectively) that specifically bind to the 3'-untranslated region of GAP-43 mRNA. In this study, using a specific monoclonal antibody, we now show that the 40-kDa proteins are members of the Elav-like protein family. This family of specific RNA-binding proteins comprise three neural(More)
PURPOSE Identify risk factors for obesity across the lifespan for individuals with spina bifida. METHODS Cross sectional chart review study of 203 patients aged 6-58 years. Obesity was based on body mass index. Rates were calculated for children aged 6-11 years; adolescents aged 12-19 years and adults aged > 20 years. Chi-square analyses were used to(More)
The first bone marrow transplantation in Latin America was performed more than 30 years ago and since then several countries have started transplant programs. The Center for International Blood and Marrow Transplant Research captured information on 13,473 transplants performed in Latin America from 1981 to 2009. The current report summarizes this activity.(More)
Hematopoietic cell transplantation (HCT) is a complex procedure that requires availability of adequate infrastructure, personnel, and resources at transplantation centers. We conducted a national survey of transplantation centers in the United States to obtain data on their personnel, infrastructure, and care delivery models. A 42-item web-based survey was(More)
OBJECTIVE To determine the age-specific incidence, prevalence, and characteristics of fractures in persons with spina bifida. DESIGN Year-long historical cross-sectional study. SUBJECTS Two hundred twenty-one consecutive patients aged 2-58 years evaluated in 2003 at a regional referral center. Twenty percent (n=44) were children age 2-10 years; 30%(More)
Im folgenden wird der Einsatz eines Prototypen zur formalen Verifikation von ASCET-SD-Modellen im Kontext der aktuell von BMW entwickelten Aktivlen-kung [EPK + 02] geschildert. Der Prototyp wurde zur¨Uberprüfung sicherheitsrelevan-ter Eigenschaften der Abschaltlogik verwendet, welche ein zentraler Bestandteil der Steuerung der Aktivlenkung ist.
The development of PTLD is a rare severe adverse event following ASCT. We report on a child with DS who developed PTLD following autologous transplant for relapsed Hodgkin's disease. He was successfully treated with cyclophosphamide, prednisone and rituximab. We also present a comprehensive review of the literature of PTLD in pediatric patients following(More)
Increasing demand for dynamically controlled safety features, passenger comfort, and operational convenience in upper class automobiles requires an intensive use of electronic control units including software portions. Modeling, simulation, rapid prototyping, and verification of the software need new technologies to guarantee passenger security and to(More)
Iron overload is a major toxicity of chronic transfusions. Myocardial iron overload is associated with cardiac dysfunction. Cardiac and liver magnetic resonance imaging (MRI) was performed on 14 chronically transfused sickle cell disease (SCD) and non-sickle cell disease (non-SCD) patients seen at Vanderbilt Children's Hospital from 1 January 2000 to 10(More)
BACKGROUND Little is known about adherence to guidelines recommending yearly screening with transcranial Doppler (TCD) ultrasonography to detect stroke risk for children with severe sickle cell disease. The objective was to determine the proportion of children with hemoglobin SS (HbSS) or sickle-β(0) -thalassemia (HbSβ(0) ) aged 2-16 years who received(More)