Michael E. Nelson

Publications10
h-index5
Citations375
Highly Influential Citations13
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Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
TLDR
The results suggest that structure-based methods may prioritize weak-but-novel chemotypes in unbiased library screens, and it may be the physical behavior of organic molecules, not their reactivity, that accounts for most screening artifacts.
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Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade
TLDR
This is, to the authors' knowledge, the first report of a large-scale HTS to identify lead compounds for a helminthic disease, and provides a paradigm that can be used to jump-start development of novel therapeutics for other neglected tropical diseases.
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Emerging drugs of abuse.
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Emerging drugs of abuse.
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Melanotan II injection resulting in systemic toxicity and rhabdomyolysis
TLDR
A 39 year-old Caucasian male injected subcutaneously 6 mg of Melanotan II purchased over the Internet in an attempt to darken his skin during wintertime resulted in systemic toxicity including apparent sympathomimetic symptoms, rhabdomyolysis, and renal dysfunction.
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Parenteral Hydrocarbon Injection and Associated Toxicities: Two Case Reports
TLDR
A pair of cases and associated visual images of complications from intravenous (IV) and subcutaneous (SC) WD-40 injection are presented and complications from parenteral hydrocarbon exposures, in particular pulmonary injury and local tissue reactions are discussed.
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Longitudinal impact of a pre‐populated default quantity on emergency department opioid prescriptions
TLDR
This data indicates that a pre‐populated default quantity may decrease opioid amounts on discharge prescriptions from the emergency department (ED) but the longitudinal effect of defaulted quantities has not been described in the literature.
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Response to Letter to the Editor regarding “Melanotan II injection resulting in systemic toxicity and rhabdomyolysis” in Clinical Toxicology 2012; 50(10):1169–73.
TLDR
In direct response to your questions, the patient did not exhibit any penile erections nor any back-arching behavior during his course in the emergency department or observed in the intensive care unit, and did, however, have diffuse muscle tremors and intense diaphoresis.
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Atlas of select poisonous plants and mushrooms.
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Practice Guidelines Chest Physicians Evidence-Based Clinical Thrombosis, 9th ed: American College of Antithrombotic Therapy and Prevention of Antithrombotic Therapy for VTE Disease :