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The plasma protein binding of phenytoin was studied in 40 adult patients with varying degrees of renal function impairment. The patients had stable renal function and no other condition known to alter phenytoin binding. Binding was measured by equilibrium dialysis, and the apparent affinity constant was calculated using the binding data and the measured(More)
We describe a simple, reproducible, and low-cost test for xerostomia, which involves chewing on a folded sterile sponge for 2 minutes. Saliva production is quantitated by weighing the sponge before and after chewing. Normal control subjects produced greater than or equal to 2.75 gm of saliva in 2 minutes. Three of 32 consecutive, unselected outpatients in(More)
Unlike inhaled beta 2-agonists, more studies need to be performed before the action of systemic beta 2-agonists on athletic performance can be assessed accurately. Experiments in animals with oral clenbuterol have shown augmentation in muscle bulk across numerous species, but human studies cannot confirm similar muscle mass enlargement in healthy men.(More)
The linear mixing model (LMM) is a well-known and useful method for decomposing spectra in a hyperspectral image into the sum of their constituents, or endmembers. Mathematically, if the spectra are represented as n-dimensional vectors, then the LMM implies that the set of endmembers defines a basis or coordinate system for the set of spectra. Because the(More)
We have developed a new and innovative technique for combining a high-spatial-resolution multispectral image with a lower-spatial-resolution hyperspectral image. The approach, called CRISP, compares the spectral information present in the multispectral image to the spectral content in the hyperspectral image and derives a set of equations to approximately(More)
We measured procainamide (I) and its metabolite, N-acetylprocainamide (II), in human serum samples by solvent extraction, high-performance liquid chromatography on a reverse phase column, and detection at 280 nm, with use of external standards. The method requires 0.2 ml of serum and is sensitive to 0.3 mg of I and 0.6 mg of II per liter of serum, with(More)
Apparent digoxin was measured in the serum of 21 patients receiving spironolactone and in 21 controls, by use of a sequential-saturation 3H-radioimmunoassay (RIA) and an equilibrium 125I-RIA. No patient had been given digoxin for at least four weeks. "Digoxin" values in the former group were significantly (p less than 0.05) higher than in the control group,(More)