Michael E. Moody

Learn More
The rate of decay of genetic variation is determined for randomly mating autotetraploid populations of finite size, and the equilibrium homozygosity under mutation and random drift is calculated. It is shown that heterozygosity is lost at a slower rate than in diploid populations, and that the equilibrium heterozygosity with mutation and random drift is(More)
A kinetic model for axonemal motion based upon a four-state mechanochemical cycle of dynein with two active sites is described. Our model analysis determines the pseudo-steady-state concentrations of enzyme species for specified rate constants, most of which are experimentally determined, with given substrate and product concentrations. The proportion of(More)
We have formulated a very general mathematical model to analyze the evolution of transposable genetic elements in prokaryotic populations. Transposable genetic elements are DNA sequences able to replicate and insert copies of themselves at new locations in the genome. This work characterizes the equilibrium distribution of copy number under the influence of(More)
The genetic cost of sexual reproduction has been attributed to two causes in mathematical formulations: male function or genome dilution. We develop and analyse a genetic model that shows that both costs occur, depending upon the conditions. The model differs from previous formulations in that the level of output and fertilization success of male gametes(More)
A discrete-time multitype branching process model is presented for the evolution of transposable elements in haploid populations. An individual is classified as type i if it possesses i copies of the TE, i greater than or equal to 0. The general model incorporates copy-dependent selection and transposition, and recursion relations are derived for the(More)
We investigate a general model describing coevolutionary interaction between a haploid population and a diploid population, each with two alleles at a single locus. Both species are allowed to evolve, with the fitness of the genotypes of each species assumed to depend linearly on the frequencies of the genotypes of the other species. We explore the(More)
Most asexual plants retain male sexual function, albeit at levels much lower than their sexual counterparts. This phenomenon has not typically received full representation in mathematical models of the cost of sex. We formulate and analyze a genetic model of reproductive mode in order to study the evolutionary dynamics of populations consisting of both(More)
Vanadate (+5) is a potent inhibitor of a variety of ATPases including dynein ATPase. We describe a method useful for estimating the functional dissociation rate of vanadate from the active site which does not rely on classical physical separation techniques. The method involves spectrophotometrically monitoring the enzymatic activity as the inhibitor(More)
The resulting algorithm is sufÞciently fast for use on personal computers and allows control of parameters by the user. We exhibit the results of testing the algorithm on simulated MRI scans of a typical human brain and on contrived data structures designed to test the limitations of the model. Filtering distortions and inaccurate modeling due to(More)