Michael E. Kowalok

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We have developed an efficient treatment-planning algorithm for prostate implants that is based on region of interest (ROI) adjoint functions and a greedy heuristic. For this work, we define the adjoint function for an ROI as the sensitivity of the average dose in the ROI to a unit-strength brachytherapy source at any seed position. The greedy heuristic(More)
Reports produced before January 1, 1996, may be purchased by members of the public from the following source. Reports are available to DOE employees, DOE contractors, Energy Technology Data Exchange (ETDE) representatives, and International Nuclear Information System (INIS) representatives from the following source. This report was prepared as an account of(More)
We continue our work on the development of an efficient treatment-planning algorithm for prostate seed implants by incorporation of an automated seed and needle configuration routine. The treatment-planning algorithm is based on region of interest (ROI) adjoint functions and a greedy heuristic. As defined in this work, the adjoint function of an ROI is the(More)
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