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Ischemic preconditioning (Pre-con) is an adaptive response triggered by a brief ischemia applied before a prolonged coronary occlusion. We tested the hypothesis that repetitive ischemia applied during early reperfusion (R), i.e. post-conditioning (Post-con), is cardioprotective by attenuating R injury. In anesthetized open-chest dogs, the LAD was occluded(More)
We have shown that intermittent interruption of immediate reflow at reperfusion (i.e., postconditioning) reduces infarct size in in vivo models after ischemia. Cardioprotection of postconditioning has been associated with attenuation of neutrophil-related events. However, it is unknown whether postconditioning before reoxygenation after hypoxia in cultured(More)
BACKGROUND Hybrid coronary revascularization (HCR) involves a combination of surgical and percutaneous techniques, which in selected patients may present an alternative to conventional coronary artery bypass grafting (CABG). METHODS AND RESULTS Patients were included who underwent HCR (staged/concurrent) or isolated CABG in the Society of Thoracic(More)
OBJECTIVE The optimal level of glycemic control needed to improve outcomes in cardiac surgery patients remains controversial. RESEARCH DESIGN AND METHODS We randomized patients with diabetes (n = 152) and without diabetes (n = 150) with hyperglycemia to an intensive glucose target of 100-140 mg/dL (n = 151) or to a conservative target of 141-180 mg/dL (n(More)
To the Editor: I read with interest the study by Kitamura et al published in a recent issue of Circulation. 1 This nationwide, population-based study found significantly higher rate of favorable neurological outcome in the conventional-cardiopulmonary resuscitation (CPR) group compared to the compression-only-CPR group for out-of-hospital cardiac arrest(More)
BACKGROUND Prolonged deep hypothermic circulatory arrest is known to cause neurological injury. Hypoxia inducible factor, a transcription factor that mediates adaptive changes during hypoxia, is neuroprotective in models of ischemic brain injury, in part by upregulating erythropoietin. This study tested the hypothesis that upregulation of hypoxia inducible(More)
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