Michael E. Baldwin

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Immunization with live-attenuated Plasmodium sporozoites completely protects against malaria infection. Genetic engineering offers a versatile platform to create live-attenuated sporozoite vaccine candidates. We previously generated a genetically attenuated parasite (GAP) by deleting the P52 and P36 genes in the NF54 wild-type (WT) strain of Plasmodium(More)
During the 2005 NOAA Hazardous Weather Testbed Spring Experiment two different high-resolution configurations of the Weather Research and Forecasting-Advanced Research WRF (WRF-ARW) model were used to produce 30-h forecasts 5 days a week for a total of 7 weeks. These configurations used the same physical parameterizations and the same input dataset for the(More)
The spatial structure of bias errors in numerical model output is valuable to both model developers and operational forecasters, especially if the field containing the structure itself has statistical significance in the face of naturally occurring spatial correlation. A semi-parametric Monte Carlo method, along with a moving blocks bootstrap method is used(More)
OBJECTIVE HIV encephalitis is observed in approximately one-half of AIDS autopsies. Although most investigators would agree that central nervous system (CNS) macrophages are the predominant infected cell in HIV encephalitis, there remains some controversy regarding whether other CNS cells can be infected by HIV and thus show the molecular characteristics of(More)
Plasmodium vivax malaria is characterized by periodic relapses of symptomatic blood stage parasite infections likely initiated by activation of dormant liver stage parasites-hypnozoites. The lack of tractable P. vivax animal models constitutes an obstacle in examining P. vivax liver stage infection and drug efficacy. To overcome this obstacle, we have used(More)
The liver stages of Plasmodium parasites are important targets for the development of anti-malarial vaccine candidates and chemoprophylaxis approaches that aim to prevent clinical infection. Analyzing the impact of interventions on liver stages in the murine malaria model system Plasmodium yoelii has been cumbersome and requires terminal procedures. In vivo(More)
Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by these infection-engendered innate responses.(More)
The impact of parameterized convection on Eta Model forecast soundings is examined. The Betts–Miller– Janjić parameterization used in the National Centers for Environmental Prediction Eta Model introduces characteristic profiles of temperature and moisture in model soundings. These specified profiles can provide misleading representations of various(More)
Trends in severe thunderstorms and the associated phenomena of tornadoes, hail, and damagingwinds have been difficult to determine because of themany uncertainties in the historical eyewitness-report-based record. The authors demonstrate how a synthetic record that is based on high-resolution numerical modeling may be immune to these uncertainties.(More)