Michael Dority

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Because the mechanisms of A beta degradation in normal and Alzheimer's disease brain are poorly understood, we have examined whether various cortical cells are capable of processing this peptide. Rat microglia and astrocytes, as well as the human THP-1 monocyte cell line, degraded A beta 1-42 added to culture medium. In contrast, neither rat cortical(More)
Activated microglia surrounding amyloid beta-containing senile plaques synthesize interleukin-1, an inflammatory cytokine that has been postulated to contribute to Alzheimer's disease pathology. Studies have demonstrated that amyloid beta treatment causes increased cytokine release in microglia and related cell cultures. The present work evaluates the(More)
Amyloid beta peptide (A beta), which is deposited as insoluble fibrils in senile plaques, is thought to play a role in the neuropathology of Alzheimer's disease. We have developed a model in which rat embryonic cerebral cortical or hippocampal neurons are seeded onto culture dishes containing deposits of substrate-bound, fibrillar A beta. The neurons(More)
Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus possess less potential for the side effects associated with MAO inhibition. The title compound (14) showed(More)
Bacterial infections by Flexibacter and Vibrio species are major causes of mortalities in Atlantic halibut (Hippoglossus hippoglossus L.) larviculture. Egg surface disinfection is a possible prophylactic treatment. This article summarizes and reviews several experimel1ls concerning causes of mortality of Atlantic halibut eggs and larvae.
We have shown previously that in infected HEL cells varicella-zoster virus (VZV) causes a shift from polar to neutral lipid synthesis and that some strains of the virus depressed total lipid synthesis. In this report we show that VZV produces a similar effect on the lipid metabolism of infected human embryonic kidney cells. The pattern of lipid synthesis in(More)
The present study investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationships of a prototype biotin carboxylase (BC) inhibitor, PD-0162819, against Haemophilus influenzae 3113 in static concentration time-kill (SCTK) and one-compartment chemostat in vitro infection models. H. influenzae 3113 was exposed to PD-0162819 concentrations of 0.5 to 16×(More)
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