• Publications
  • Influence
The amygdala
It’s also now clear that the basolateral amygdala is involved in more positive behaviors, such as in approaching things that appeal. Expand
Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Data will be reviewed using the acoustic startle reflex in rats and humans based on attempts to operationally define fear vs anxiety, finding that symptoms of clinical anxiety are better detected in sustained rather than phasic fear paradigms. Expand
Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats
Results indicate that treatments that promote NMDA receptor activity after either systemic or intra-amygdala administration promote the extinction of conditioned fear. Expand
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety.
It is suggested that, although the bed nucleus of the stria terminalis may not be necessary for rapid-onset, short-duration behaviors which occur in response to specific threats, it may mediate slower-onsets, longer-lasting responses that frequently accompany sustained threats, and that may persist even after threat termination. Expand
Behavioral and Neural Analysis of Extinction
This review considers the behavioral, cellular, and molecular literatures on extinction and presents the most recent advances in understanding while identifying issues that require considerable further research. Expand
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.
These pilot data provide initial support for the use of acute dosing of DCS as an adjunct to exposure-based psychotherapy to accelerate the associative learning processes that contribute to correcting psychopathology. Expand
Activation of the left amygdala to a cognitive representation of fear
The results suggest that the neural substrates that support conditioned fear across species have a similar but somewhat different role in more abstract representations of fear in humans. Expand
Neural systems involved in fear and anxiety measured with fear-potentiated startle.
  • Michael Davis
  • Psychology, Medicine
  • The American psychologist
  • 1 November 2006
A good deal is now known about the neural circuitry involved in how conditioned fear can augment a simple reflex (fear-potentiated startle) and both extinction in rats and exposure-based psychotherapy in humans are facilitated by an NMDA-partial agonist called D-cycloserine. Expand
Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
The results demonstrate that the eCB system can be modulated to enhance emotional learning, and suggest that eCB modulators may be therapeutically useful as adjuncts for exposure-based psychotherapies such as those used to treat Post-Traumatic Stress Disorder and other anxiety disorders. Expand
Neurotransmission in the rat amygdala related to fear and anxiety
A better understanding of brain systems that inhibit the amygdala, as well as the role of its very high levels of peptides, might eventually lead to the development of more effective pharmacological strategies for treating clinical anxiety and memory disorders. Expand