Learn More
Here we describe a novel microarray platform that integrates all functions needed to perform any array-based experiment in a compact instrument on the researcher's laboratory benchtop. Oligonucle otide probes are synthesized in situ via a light- activated process within the channels of a three-dimensional microfluidic reaction carrier. Arrays can be(More)
The purpose of the study was the direct detection of intact protein adducts-resulting from in-vitro incubations of flunoxaprofen- and benoxaprofen glucuronides in biological materials or originating from in vivo studies-by polyacrylamide gel electrophoresis (SDS-PAGE) followed by blotting and fluorescent scan, presumably yielding better specificity for the(More)
Aberrant DNA methylation at CpG dinucleotides can result in epigenetic silencing of tumour suppressor genes and represents one of the earliest events in tumourigenesis. To date, however, high-throughput tools that are capable of surveying the methylation status of multiple gene promoters have been restricted to a limited number of cytosines. Here, we(More)
Because of previously observed species differences in rhein tolerability, with rabbits being very susceptible to kidney disturbances, in vivo and in vitro biotransformation studies were performed to find out whether the differences in the undesired effects of rhein are associated with qualitative, species-dependent differences in its metabolism. First hints(More)
Aberrant DNA methylation at CpG dinucleotides can result in epigenetic silencing of tumour suppressor genes and represents one of the earliest events in tumourigenesis. To date, however, high-throughput tools that are capable of surveying the methylation status of multiple gene promoters have been restricted to a limited number of cytosines. Here, we(More)
Current research has highlighted that magnesium and its alloys as biodegradable material are highly suitable for biomedical applications. The new material fully degrades into nontoxic elements and offers material properties matching those of human bone tissue. As biomedical implants are rather small and complex in shape, the metal injection molding (MIM)(More)
The current physiological in vitro tests of Mg degradation follow the procedure stated according to the ASTM standard. This standard, although useful in predicting the initial degradation behavior of an alloy, has its limitations in interpreting the same for longer periods of immersion in cell culture media. This is an important consequence as the alloy's(More)
Inheritance of vertical fiber hide defect (VFHD), a structural defect in collagen fiber orientation that causes weakness and reduced value of leather, was examined using histological data on hide biopsies obtained from 465 Hereford cattle by 65 sires. The data set included 44 offspring-dam pairs, for which VFHD phenotypes had been diagnosed on both the(More)
  • 1