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The Amphimedon queenslandica genome and the evolution of animal complexity
Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from theExpand
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The Selaginella Genome Identifies Genetic Changes Associated with the Evolution of Vascular Plants
The genome sequence of a lycophyte hints at ancient evolutionary transitions. Vascular plants appeared ~410 million years ago, then diverged into several lineages of which only two survive: theExpand
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Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases
A genomic survey suggests that cytoplasmic tyrosine kinases diversified before the establishment of multicellular organisms. Tracing Tyrosine Kinase Evolution Protein tyrosine kinases, which areExpand
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Fine-mapping cis-regulatory variants in diverse human populations
Genome-wide association studies (GWAS) are a powerful approach for connecting genotype to phenotype. Most GWAS hits are located in cis-regulatory regions, but the underlying causal variants and theirExpand
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Fine-mapping cis-regulatory variants in diverse human populations
Genome-wide association studies (GWAS) are a powerful approach for connecting genotype to phenotype. Most GWAS hits are located in cis-regulatory regions, but the underlying causal variants and theirExpand
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Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping
Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create aExpand
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Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci
Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we haveExpand