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Hepatocyte nuclear factor 4alpha (HNF4alpha) (NR2A1), an orphan member of the nuclear receptor superfamily, binds DNA exclusively as a homodimer even though it is very similar in amino acid sequence… Continue Reading
Transcription factors, such as nuclear receptors, often exist in various forms that are generated by highly conserved splicing events. Whereas the functional significance of these splicing variants… Continue Reading
For most ligand-dependent nuclear receptors, the status of endogenous ligand modulates the relative affinities for corepressor and coactivator complexes. It is less clear what parameters modulate the… Continue Reading
Paleontology has long had a troubled relationship with evolutionary biology. Suffering from a reputation as a second-tier science and conjuring images of fossil collectors and amateurs who dig up… Continue Reading
Michael Ruse is one of the foremost Charles Darwin scholars of our time. For forty years he has written extensively on Darwin, the scientific revolution that his work precipitated, and the nature and… Continue Reading