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Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
From Yeast to Therapeutic? Yeast has shown some promise as a model system to generate lead compounds that could have therapeutic potential for the cellular problems associated with neurodegenerativeExpand
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Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors.
Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation,Expand
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Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis
Nitric oxide (NO) and hydrogen peroxide (H2O2) are synthesized within cardiac myocytes and play key roles in modulating cardiovascular signaling. Cardiac myocytes contain both the endothelial (eNOS)Expand
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Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?
  BACKGROUND AND PURPOSE: Posttranslational modifications of cysteine residues represent a major aspect of redox biology, and their reliable detection is key in providing mechanistic insights. TheExpand
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Reactive sulfur species (RSS): persulfides, polysulfides, potential, and problems.
Sulfur is a crucial element in biology due to its unique properties and wide range of accessible oxidation states. This reactivity gives rise to the generation of reactive sulfur species (RSS), whichExpand
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Acid Catalysis in Basic Solution: A Supramolecular Host Promotes Orthoformate Hydrolysis
Although many enzymes can promote chemical reactions by tuning substrate properties purely through the electrostatic environment of a docking cavity, this strategy has proven challenging to mimic inExpand
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Proton-mediated chemistry and catalysis in a self-assembled supramolecular host.
Synthetic supramolecular host assemblies can impart unique reactivity to encapsulated guest molecules. Synthetic host molecules have been developed to carry out complex reactions within theirExpand
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Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells.
Hydrogen sulfide (H(2)S) is an important biological messenger but few biologically-compatible methods are available for its detection. Here we report two bright fluorescent probes that are selectiveExpand
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A practical guide to working with H2S at the interface of chemistry and biology.
Hydrogen sulfide (H2S) is the most recently accepted endogenously produced gasotransmitter and is now implicated in a variety of physiological functions. In this tutorial review, our goal is toExpand
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Understanding Hydrogen Sulfide Storage: Probing Conditions for Sulfide Release from Hydrodisulfides
Hydrogen sulfide (H2S) is an important biological signaling agent that exerts action on numerous (patho)physiological processes. Once generated, H2S can be oxidized to generate reductant-labileExpand
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