Michael D Platt

Learn More
Temperature sensation has a strong impact on animal behavior and is necessary for animals to avoid exposure to harmful temperatures. It is now well known that thermoTRP (transient receptor potential) channels in thermosensory neurons detect a variable range of temperature stimuli. However, little is known about how a range of temperature information is(More)
Decision making involves selection from sets of options based on current evidence about the state of the world and estimates of the value or utility of different outcomes. The neural correlates of evidence assessment that guide simple perceptual judgments are now well understood, and we argue that this process can serve as a simple model for organizing(More)
Despite constant sensory input from our busy environment, the human mind has the capacity to overcome external constraints in favor of a different time, place, or perspective. By imagining what was or what might be, simulating the mental states of other people, and reflecting on our emotions, we become better adapted to predict our future mental states and(More)
" Cognitive control " describes endogenous guidance of behavior in situations where routine stimulus-response associations are suboptimal for achieving a desired goal. The computational and neural mechanisms underlying this capacity remain poorly understood. The present dissertation examines recent advances stemming from the application of a statistical,(More)
Pain and symptom management at the end of life remains suboptimal.Pain physicians are uniquely placed to provide interventions for patients with difficult to manage pain.Interventions such as acupuncture, radiofrequency ablation, neurolysis together with regional analgesia including neuraxial techniques and spinal cordotomy may provide the patient with(More)
operates in a number of them and earns there only around £30 million. Despite the concerns, many still believe Witty's pledge marks a major step forward for neglected diseases and developing countries. " He is breaking the mould in validating the concept of patent pools, " said Rohit Malpani at Oxfam's access to medicines campaign. " It is a big step(More)
  • 1