Michael D. Moore

William S. James2
Sally A. Cowley2
Bonnie van Wilgenburg2
John McLauchlan1
2William S. James
2Sally A. Cowley
2Bonnie van Wilgenburg
Learn More
Once transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host cell sites to be translated or to find a partner RNA for copackaging to form newly generated viruses. In this report, we sought to delineate the location where HIV-1 RNA initiates dimerization and the influence of the RNA transport pathway used by the virus on(More)
Chronic granulomatous disease (CGD) is a rare genetic disease characterized by severe and persistent childhood infections. It is caused by the lack of an antipathogen oxidative burst, normally performed by phagocytic cells to contain and clear bacterial and fungal growth. Restoration of immune function can be achieved with heterologous bone marrow(More)
  • Bonnie van Wilgenburg, Iris Scherwitzl, Edward C. Hutchinson, Tianqi Leng, Ayako Kurioka, Corinna Kulicke +49 others
  • 2016
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme(More)
Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically manipulating primary macrophages. We developed an effective genetic approach to manipulate the sub-cellular distribution of CD4 in macrophages, and investigated how this affects the HIV-1 entry pathway.(More)
Statistical methods for reconstructing speech at the phoneme level are used to find missing phonemes that are removed from sentences in the TIMIT corpus. Probabilities for the occurrence of the missing phoneme(s) are generated and the most likely candidate(s) selected to reconstruct the sentence. Method includes symmetric and asymmetric 'confidence(More)
  • 1