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The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human cancers and for which detailed genetic and pharmacological annotation is available. Here we describe the(More)
The transaction ordering problem of the original PCI 2.1 standard bus speciication violates the desired correctness property of maintaining the so called`Producer/Consumer' relationship between writers and readers of data. This violation stems mainly from the so called completion stealing problem, rst identiied and solved by Corella et al 4], and supported(More)
Bmi-1 and Mel-18 are structural homologues that belong to the Polycomb group of transcriptional regulators and are believed to stably maintain repression of gene expression by altering the state of chromatin at specific promoters. While a number of clinical and experimental observations have implicated Bmi-1 in human tumorigenesis, the role of Mel-18 in(More)
Automated trust negotiation is the process of establishing trust between entities with no prior relationship through the iterative disclosure of digital credentials. One approach to negotiating trust is for the participants to exchange access control policies to inform each other of the requirements for establishing trust. When a policy is received at(More)
Recent advances in parallel model checking for liveness properties achieve significant capacity increases over sequential model checkers. However, the capacity of parallel model checkers is in turn limited by available aggregate memory and network bandwidth. We propose a new parallel algorithm that sacrifices complete coverage for increased capacity to find(More)
We present an incremental proof of the producer/consumer property for the PCI protocol. In the incremental proof, a corrected model of the multi-bus PCI 2.1 protocol is shown to be a refinement of the producer/consumer property. Multi-bus PCI must be corrected because the original PCI specification violates the producer/consumer property. The final model of(More)
We address the problem of directable weathering of exposed concave rock for use in computer-generated animation or games. Previous weathering models that admit concave surfaces are computationally inefficient and difficult to control. In nature, the spheroidal and cavernous weathering rates depend on the surface curvature. Spheroidal weathering is fastest(More)
The Murϕ-based Hopper tool is a general purpose explicit model checker. Hopper leverages Murϕ's class structure to implement new algorithms. Hopper differs from Murϕ in that it includes in its distribution published parallel and disk based algorithms, as well as several new algorithms. For example, Hop-per includes parallel dynamic partitioning, cooperative(More)