Michael D. Joner

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It is often important to rapidly detect an increase in the incidence rate of a given disease or other medical condition. It has been shown that when disease counts are sequentially available from a single region, a univariate control chart designed to detect rate increases, such as a one-sided cumulative sum chart, is very effective. When disease counts are(More)
OBJECTIVE To validate optical coherence tomography (OCT) imaging for assessment of vascular healing in a preclinical animal model and human autopsy cases and to translate the findings to the assessment of vascular healing after drug-eluting stent implantation in clinical practice. APPROACH AND RESULTS Drug-eluting and bare metal stents were imaged 28 and(More)
OBJECTIVE Although emerging data from preclinical and clinical studies suggests a reduction of in-stent restenosis with peroxisome proliferator-activated receptor (PPAR)-gamma agonists, the reduction of neointimal growth via anti-inflammatory mechanisms has not been explored. METHODS AND RESULTS Hypercholesterolemic New Zealand White rabbits (n=45)(More)
BACKGROUND Stent thrombosis (ST) is a rare but serious complication following percutaneous coronary intervention. Analysis of thrombus composition from patients undergoing catheter thrombectomy may provide important insights into the pathological processes leading to thrombus formation. We performed a large-scale multicentre study to evaluate thrombus(More)
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. The pathogenesis of CAD relates to the presence of atherosclerotic plaques in the coronary arteries, which are most frequently treated today by percutaneous coronary intervention. Small vessel disease treatment represents one-third of all percutaneous coronary(More)
An unanticipated result of researching transiting planet candidates from the Kepler spacecraft mission was the discovery of several variable objects in the fields of some of the targets. One particular object, which it was determined had not been previously documented, had a light curve that indicated it was a contact eclipsing binary star system. We found(More)
Here we present observations of 7 large Kuiper Belt Objects. From these observations, we extract a point source catalog with ∼ 0.01 " precision, and astrometry of our target Kuiper Belt Objects with 0.04 − 0.08 " precision within that catalog. We have developed a new technique to predict the future occurrence of stellar occultations by Kuiper Belt Objects.(More)
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