Michael D. Howell

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Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia (<1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of neither among 11,490 consecutive adult(More)
Atopic dermatitis (AD) is characterized by a defective skin barrier which allows increased allergen and pathogen penetration. Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity. In this study, we demonstrate that the gene and protein expression of LOR and IVL is significantly decreased in involved (LOR:(More)
  • Springer-Verlag, Tal Mandelbaum, Joon Lee, Phd, Daniel J Scott Phd, Roger G Mark +6 others
  • 2013
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Disclosures: None of the authors have any financial interests or potential conflicts to disclose Abstract Purpose: The observation periods and thresholds on serum creatinine and urine output defined in the Acute Kidney Injury Network (AKIN)(More)
OBJECTIVE To determine if earlier administration of epinephrine (adrenaline) in patients with non-shockable cardiac arrest rhythms is associated with increased return of spontaneous circulation, survival, and neurologically intact survival. DESIGN Post hoc analysis of prospectively collected data in a large multicenter registry of in-hospital cardiac(More)
INTRODUCTION Recently, red cell distribution width (RDW), a measure of erythrocyte size variability, has been shown to be a prognostic marker in critical illness. The aim of this study was to investigate whether adding RDW has the potential to improve the prognostic performance of the simplified acute physiology score (SAPS) to predict short- and long-term(More)
OBJECTIVE An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infection (CDI) has been a common finding of many, but not all studies. We hypothesized that association between acid-suppression medications and CDI is due to the residual confounding in comparison between patients with infection to those without,(More)
Medical algorithms, technical skills, and repeated training are the classical cornerstones for successful cardiopulmonary resuscitation (CPR). Increasing evidence suggests that human factors, including team interaction, communication, and leadership, also influence the performance of CPR. Guidelines, however, do not yet include these human factors, partly(More)
BACKGROUND There is an increase in admission rate for elderly patients to the ICU. Mortality rates are lower when more liberal ICU admission threshold are compared to more restrictive threshold. We sought to describe the temporal trends in elderly admissions and outcomes in a tertiary hospital before and after the addition of an 8-bed medical ICU. METHODS(More)
CONTEXT We noted a bimodal relationship between mortality and shock index (SI), the ratio of heart rate to systolic blood pressure. AIMS To determine if extremes of SI can predict mortality in trauma patients. SETTINGS AND DESIGNS Retrospective evaluation of adult trauma patients at a tertiary care center from 2000 to 2012 in the United States. (More)
BACKGROUND Dyspnea (breathing discomfort) can be as powerfully aversive as pain, yet is not routinely assessed and documented in the clinical environment. Routine identification and documentation of dyspnea is the first step to improved symptom management and it may also identify patients at risk of negative clinical outcomes. OBJECTIVE To estimate the(More)