Michael D. Forrest

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In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is(More)
Without synaptic input, Purkinje neurons can spontaneously fire in a repeating trimodal pattern that consists of tonic spiking, bursting and quiescence. Climbing fiber input (CF) switches Purkinje neurons out of the trimodal firing pattern and toggles them between a tonic firing and a quiescent state, while setting the gain of their response to Parallel(More)
An approach to investigate brain function/dysfunction is to simulate neuron circuits on a computer. A problem, however, is that detailed neuron descriptions are computationally expensive and this handicaps the pursuit of realistic network investigations, where many neurons need to be simulated. We confront this issue; we employ a novel reduction algorithm(More)
We propose that NADH will exert a specific kill action against some cancers. NADH is a natural metabolite. We envisage a low side effect profile and that NADH therapy will, additionally, combat the wastage and weakness of cancer patients, which can be the cause of death in some cases. Significantly, NADH can be administered orally and has already cleared(More)
Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a(More)
Brain neurons can transmit signals using a flow of Na + and K + ions, which produce an electrical spike called an action potential (AP) (Hodgkin and Huxley, 1952). After an AP, the Na + /K + pump resets the arrangement of Na + and K + ions back to their original positions so that the neuron is then ready to relay another AP when it is called upon to do so(More)
Cancer cells have a more hyperpolarised mitochondrial membrane potential (Ψ IM) than normal cells. Ψ IM = ~-220 mV in cancer cells as compared to ~-140 mV in normal cells. Until now it has not been known why. This paper explains this disparity, in a mathematical framework, and identifies molecular targets and operations unique to cancer cells. These are(More)
I use the Nernst equation, parameterised with experimental data, to predict that cancer cells will accumulate more of a lipophilic anion than normal cells. This effect is correlated to charge number. Model cancer cells accumulate *100 more of an anion, *10 3 more di-anion, *10 6 more tri-anion, *10 8 more tetra-anion and *10 10 more penta-anion (>>1 billion(More)
Original citation: Forrest, Michael D.. (2014) Can the thermodynamic Hodgkin-Huxley Model of voltage-dependent conductance extrapolate for temperature? Computation , Volume 2 (Volume 2). pp. 47-60. Copyright and reuse: The Warwick Research Archive Portal (WRAP) makes this work of researchers of the University of Warwick available open access under the(More)
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