Michael D. Boska

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Single-voxel proton spectra of the human brain were recorded in five subjects at both 1.5T and 3.0T using the STEAM pulse sequence. Data acquisition parameters were closely matched between the two field strengths. Spectra were recorded in the white matter of the centrum semiovale and in phantoms. Spectra were compared in terms of resolution and(More)
This study has measured the apparent 31P T1 times at 1.5 T in human gastrocnemius/soleus muscle groups at rest, during exercise, and during recovery from a 90-sec submaximal plantar flexion exercise. T1 times were measured with a 10-sec time resolution in 11 normally active volunteers using a surface coil with a nine-point progressive saturation technique.(More)
The goal of these experiments was to investigate the relationship of ATP, phosphocreatine (PCr), inorganic phosphate (Pi), monobasic phosphate (H2PO4-), and pH to human muscle fatigue. Phosphates and pH were measured in adductor pollicis using 31P nuclear magnetic resonance at 2.0 Tesla. The force of muscle contraction was simultaneously measured with a(More)
Early diagnosis of Parkinson's disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect >50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess(More)
In vitro and animal model data demonstrate that valproic acid (VPA) can ameliorate HIV-associated neurotoxicity. The authors conducted a pilot 10-week placebo-controlled study of VPA 250 mg twice daily in 22 HIV-infected individuals with (n = 16) and without (n = 6) cognitive impairment. VPA was safe and well tolerated, with trends toward improved(More)
Neuroinflammatory processes play a significant role in the pathogenesis of Parkinson's disease (PD). Epidemiologic, animal, human, and therapeutic studies all support the presence of an neuroinflammatory cascade in disease. This is highlighted by the neurotoxic potential of microglia . In steady state, microglia serve to protect the nervous system by acting(More)
Net forward adenosine triphosphate (ATP) production rates were calculated from 31P nuclear magnetic resonance spectroscopy (MRS) kinetic data collected with 1-8 s time resolution during isometric voluntary contractions of the human gastrocnemius/soleus muscle group. Volume normalized muscle output (Newtons/ml) was then divided by the calculated net ATP use(More)
We investigated the metabolic basis of human muscular fatigue and recovery utilizing 31P magnetic resonance spectroscopy and measurements of maximum voluntary contraction (MVC). We produced fatigue by sustained MVC for 4 minutes in 2 different muscles (adductor pollicis, tibialis anterior) and obtained similar results in both muscles. During fatiguing(More)
INTRODUCTION The purpose of the present manuscript is to test the hypothesis that arthrotropic localization and synovial cell internalization account for the unique capacity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-dexamethasone conjugate (P-Dex, a macromolecular prodrug of dexamethasone) to induce sustained amelioration of joint inflammation(More)
BACKGROUND We posit that the same mononuclear phagocytes (MP) that serve as target cells and vehicles for a host of microbial infections can be used to improve diagnostics and drug delivery. We also theorize that physical and biological processes such as particle shape, size, coating and opsonization that affect MP clearance of debris and microbes can be(More)