Arginylation is an emerging post-translational modification mediated by arginyltransferase (ATE1) that is essential for mammalian embryogenesis and regulation of the cytoskeleton. Here, we discovered that Ate1-knockout (KO) embryonic fibroblasts exhibit tumorigenic properties, including abnormally rapid contact-independent growth, reduced ability to form… (More)
In their review of female sterilization procedures, Dr. Mumford and colleagues indicate a high complication rate for laparoscopy. In my extensive experience of laparoscopy, I occasionally create emphysema of the abdominal wall and even of the omentum. Abdominal wall emphysema is totally innocuous, and the same can be said for omental emphysema. To call… (More)
Arginyltransferase 1 (Ate1) mediates protein arginylation, a poorly understood protein posttranslational modification (PTM) in eukaryotic cells. Previous evidence suggest a potential involvement of arginylation in stress response and this PTM was traditionally considered anti-apoptotic based on the studies of individual substrates. However, here we found… (More)
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