Michael D. Berginc

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UNLABELLED The standardized uptake value ratio (SUVR, or summed tissue ratio) has been used effectively in Pittsburgh compound B (PiB) PET studies to distinguish subjects who have significant amyloid-beta deposition in their brain from those who do not. Relative to quantitative measurements, advantages of the SUVR are improved study feasibility and low(More)
A major challenge in positron emission tomography (PET) amyloid imaging studies of Alzheimer's disease (AD) is the reliable detection of early amyloid deposition in human brain. Manual region-of-interest (ROI) delineation on structural magnetic resonance (MR) images is generally the reference standard for the extraction of count-rate data from PET images,(More)
Introduction: The practical usefulness of automated region-of-interest (ROI) placement for sampling of PET data is well known. Automated methods generally use one set of ROIs (for one structural MR image template), relative to the more labor intensive standard method of manual ROI creation on each subject's native MR that can be impractical for large(More)
Introduction: Amyloid (Aβ) deposition is a pathological hallmark of Alzheimer's disease (AD) that begins many years before clinical symptoms are evident. PET amyloid-imaging consistently shows substantial levels of amyloid deposition in AD and many subjects with mild cognitive impairment (MCI). These studies also indicate that the earliest amyloid(More)
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