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Whole exome sequencing by high-throughput sequencing of target-enriched genomic DNA (exome-seq) has become common in basic and translational research as a means of interrogating the interpretable part of the human genome at relatively low cost. We present a comparison of three major commercial exome sequencing platforms from Agilent, Illumina and Nimblegen(More)
This study was designed to examine the role of duration in vowel perception by testing listeners on the identification of CVC syllables generated at different durations. Test signals consisted of synthesized versions of 300 utterances selected from a large, multitalker database of /hVd/ syllables [Hillenbrand et al., J. Acoust. Soc. Am. 97, 3099-3111(More)
Whole-genome sequencing is becoming commonplace, but the accuracy and completeness of variant calling by the most widely used platforms from Illumina and Complete Genomics have not been reported. Here we sequenced the genome of an individual with both technologies to a high average coverage of ∼76×, and compared their performance with respect to sequence(More)
Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies with mouse models, we previously demonstrated that genetic variation in inflammatory responses of endothelial cells to oxidized lipids contributes importantly to atherosclerosis susceptibility. We now(More)
U87MG is a commonly studied grade IV glioma cell line that has been analyzed in at least 1,700 publications over four decades. In order to comprehensively characterize the genome of this cell line and to serve as a model of broad cancer genome sequencing, we have generated greater than 30x genomic sequence coverage using a novel 50-base mate paired strategy(More)
This article presents a robust approach to navigating at high speed across desert terrain. A central theme of this approach is the combination of simple ideas and components to build a capable and robust system. A pair of robots were developed, which completed a 212 km Grand Challenge desert race in approximately 7 h. A pathcentric navigation system uses a(More)
OBJECTIVE Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (oxPAPC) accumulates in atherosclerotic lesions and in vitro studies suggest that it mediates chronic inflammatory response in endothelial cells (ECs). The goal of our studies was to identify pathways mediating the induction of inflammatory genes by oxPAPC. METHODS AND RESULTS(More)
There are many challenges in analyzing and visualizing data from current cutting-edge general relativistic astrophysics simulations. Many of the associated tasks are time-consuming with large performance degradation due to the magnitude and complexity of the data. The Adaptable I/O System (ADIOS) is a componentization of the I/O layer that has demonstrated(More)
The purpose of the present study was to determine the contributions of fundamental frequency (f (0)) and formants in cuing the distinction between men's and women's voices. A source-filter synthesizer was used to create four versions of 25 sentences spoken by men: (1) unmodified synthesis, (2) f (0) only shifted up toward values typical of women, (3)(More)