Michael Churchill

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The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of(More)
NR3B is a modulatory subunit of the NMDA receptor, abundantly expressed in both cranial and spinal somatic motoneurons and at lower levels in other regions of the brain as well. Recently, we found the human NR3B gene (GRIN3B) to be highly genetically heterogeneous, and that approximately 10% of the normal European-American population lacks NR3B due to(More)
Tumor-propagating cells in acute leukemia maintain a stem/progenitor-like immature phenotype and proliferative capacity. Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) originate from different lineages through distinct oncogenic events such as MLL fusions and Notch signaling, respectively. We found that Zfx, a transcription factor(More)
There has recently been an increasing interest in controlling macromolecular conformations and interactions through halogen bonding. Halogen bonds are favorable electrostatic interactions between polarized, electropositive chlorine, bromine, or iodine atoms and electronegative atoms such as oxygen or nitrogen. These interactions have been likened to(More)
—Magnetic fusion could provide an inexhaustible, clean, and safe solution to the global energy needs. The success of magnetically-confined fusion reactors demands steady-state plasma confinement which is challenged by the blob-filaments driven by the edge turbulence. Real-time analysis can be used to monitor the progress of fusion experiments and prevent(More)
—A novel algorithm and implementation of real-time identification and tracking of blob-filaments in fusion reactor data is presented. Similar spatio-temporal features are important in many other applications, for example, ignition kernels in combustion and tumor cells in a medical image. This work presents an approach for extracting these features by(More)
—Magnetic fusion could provide an inexhaustible, clean, and safe solution to the global energy needs. The success of magnetically-confined fusion reactors demands steady-state plasma confinement which is challenged by the blob-filaments driven by the edge turbulence. Real-time analysis can be used to monitor the progress of fusion experiments and prevent(More)
With fusion device performance hinging on the edge pedestal pressure, it is imperative to experimentally understand the physical mechanism dictating the pedestal characteristics and to validate and improve pedestal predictive models. This Letter reports direct evidence of density and magnetic fluctuations showing the stiff onset of an edge instability(More)
—Magnetic fusion could provide an inexhaustible, clean, and safe solution to the global energy needs. The success of magnetically-confined fusion reactors demands steady-state plasma confinement which is challenged by the edge turbulence such as the blob-filaments. Real-time analysis can be used to monitor the progress of fusion experiments and prevent(More)
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