Michael Bulger

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ACF, an ISWI-Containing and ATP-Utilizing Chromatin Assembly and Remodeling Factor

Takashi Ito, Michael Bulger, Michael J. Pazin, Ryuji Kobayashi, James T. Kadonaga
Cell
1997

We describe the purification and characterization of ACF, an ATP-utilizing chromatin assembly and remodeling factor. ACF is a multisubunit factor that contains ISWI protein and is distinct from NURF,… (More)

Functional and Mechanistic Diversity of Distal Transcription Enhancers

Biological differences among metazoans and between cell types in a given organism arise in large part due to differences in gene expression patterns. Gene-distal enhancers are key contributors to… (More)

Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors.

Jessica K Tyler, Kim A. Collins, +5 authors James T. Kadonaga
Molecular and cellular biology
2001

The assembly of newly synthesized DNA into chromatin is essential for normal growth, development, and differentiation. To gain a better understanding of the assembly of chromatin during DNA… (More)

Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays.

Takashi Ito, Michael Bulger, Ryuji Kobayashi, James T. Kadonaga
Molecular and cellular biology
1996

We describe the cloning and analysis of Drosophila nucleosome assembly protein 1 (dNAP-1), a core histone-binding protein that functions with other chromatin assembly activities in a Drosophila… (More)

Enhancers: the abundance and function of regulatory sequences beyond promoters.

Michael Bulger, Mark Groudine
Developmental biology
2010

Transcriptional control in mammals and Drosophila is often mediated by regulatory sequences located far from gene promoters. Different classes of such elements - particularly enhancers, but also… (More)

The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein.

Jessica K Tyler, Michael Bulger, Rohinton T. Kamakaka, Ryuji Kobayashi, James T. Kadonaga
Molecular and cellular biology
1996

To gain a better understanding of DNA replication-coupled chromatin assembly, we have isolated the cDNA encoding the smallest (apparent molecular mass, 55 kDa; termed p55) subunit of Drosophila… (More)

"Maturational" globin switching in primary primitive erythroid cells.

Paul Kingsley, Jeffrey Malik, +5 authors James Palis
Blood
2006

Mammals have 2 distinct erythroid lineages. The primitive erythroid lineage originates in the yolk sac and generates a cohort of large erythroblasts that terminally differentiate in the bloodstream.… (More)

ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster.

Takashi Ito, Jessica K Tyler, Michael Bulger, Ryuji Kobayashi, James T. Kadonaga
The Journal of biological chemistry
1996

To gain a better understanding of the factors that can mediate chromatin assembly, we have purified and cloned a core histone-binding protein from Drosophila melanogaster embryos. This protein… (More)

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

Michael Bulger, J Hikke van Doorninck, +6 authors Mark Groudine
Proceedings of the National Academy of Sciences…
1999

In mouse and human, the beta-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences… (More)

Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.

Michael A. Bender, Michael Bulger, Jennie Close, Mark Groudine
Molecular cell
2000

We have generated mice with a targeted deletion of the beta-globin locus control region (LCR). Mice homozygous for the deletion die early in embryogenesis but can be rescued with a YAC containing the… (More)

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