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Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The general mechanisms of the UPR and its apoptotic pathways are well characterized. However, the metabolic events that occur during the(More)
The mitochondria-associated membrane (MAM) has emerged as an endoplasmic reticulum (ER) signaling hub that accommodates ER chaperones, including the lectin calnexin. At the MAM, these chaperones control ER homeostasis but also play a role in the onset of ER stress-mediated apoptosis, likely through the modulation of ER calcium signaling. These opposing(More)
— Data visualization has become an important tool for analyzing very complex data. In particular, spatial visualization enables users to view data in a intuitive manner. It has typically been used to externalize clusters and their relationships which exist in highly complex multidimensional data. We envisage that not only cluster formation and relationships(More)
The complexity and size of data is rapidly increasing in modern science, business and engineering. This has resulted in increasing demands for more sophisticated data analysis methods. Multidimensional scaling has been used to visualize large high-dimensional datasets in the form of a map. Such maps are very intuitive for us, as we are familiar with reading(More)
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