Michael Briskin

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T cell activation by intestinal dendritic cells (DC) induces gut-tropism. We show that, reciprocally, DC from peripheral lymph nodes (PLN-DC) induce homing receptors promoting CD8 T cell accumulation in inflamed skin, particularly ligands for P- and E-selectin. Differential imprinting of tissue-tropism was independent of Th1/Th2 cytokines and not restricted(More)
A characteristic feature of rheumatoid arthritis is the abundance of inflammatory cells in the diseased joint. Two major components of this infiltrate are neutrophils in the synovial fluid and macrophages in the synovial tissue. These cells produce cytokines including tumor necrosis factor alpha and other proinflammatory mediators that likely drive the(More)
Primary sclerosing cholangitis (PSC), a chronic inflammatory liver disease characterized by progressive bile duct destruction, develops as an extra-intestinal complication of inflammatory bowel disease (IBD) (Chapman, R.W. 1991. Gut. 32:1433-1435). However, the liver and bowel inflammation are rarely concomitant, and PSC can develop in patients whose colons(More)
An Abel diierential equation y 0 = p(x)y 2 + q(x)y 3 is said to have a center at a pair of complex numbers (aa b) i f y(a) = y(b) f o r a n y its solution y(x) (with the initial value y(a) small enough). Let pp q be polynomials and let P = R pp Q = R q. P and Q satisfy \Polynomial Composition condition" if there exist polynomials ~ P , ~ Q and W such that P(More)
ICOS (inducible co-stimulator molecule) is a T cell encoded member of the extended B7/CD28 superfamily that is up-regulated upon early T cell activation. Previous studies have shown that higher ICOS expression on circulating T cells, post treatment with ipilimu-mab, is associated with better clinical outcome. In complementary pre-clinical studies, efficacy(More)
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