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In the developing pancreas of human embryos and fetusses (in weeks 4 to 20 of the intrauterine life) activities of aminopeptidase A (APA) and M (APM), dipeptidyl peptidase IV (DPP IV), and gamma-glutamyl transferase (GGT) were studied in cryostat sections using methods as recommended by Lojda (J. Histochem. Cytochem. 29, 481 (1981)). In the youngest embryos(More)
The expression of PCNA was proved in some organs of human fetuses aged from 10 to 25 weeks of the intrauterine development. The distinct expression of PCNA was demonstrated in the nuclei of the myoblasts of the ventricles and atria of the fetal heart. The high expression of PCNA was found in the nuclei of the epithelial cells of the fetal bronchial tree,(More)
The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the formation of R-loops, co-transcriptional RNA-DNA products,(More)
The activities of some enzymes (phosphatases, esterases peptidases, and dehydrogenases) were studied. The activities of the enzymes in the youngest embryos (4-8 weeks) were relatively low (ALP-activity on membranes of the primitive capillary endothelium, ACP and UE activities in the cytoplasm of the epithelial reticulum cells). The DPP IV activity was(More)
Activities of the following enzymes were assessed in cryostat sections of human embryonic and fetal placentae aged 7 to 22 weeks of the intrauterine life using the standard methods recommended by Lojda et al. (1978): alkaline phosphatase (AIP), and acid phosphatase (AcP), non-specific esterase (ANE), ATP-cleaving enzymes (ATP-ase), beta-glucuronidase,(More)
OBJECTIVE To describe the current data evaluating the efficacy and safety of memantine for the prevention of primary headache disorders. DATA SOURCES A literature search using MEDLINE (1966-July 2014) and EMBASE (1973-July 2014) was conducted using the search terms memantine, headache, migraine, glutamate, and NMDA. References of identified articles were(More)