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  • Maria Cristina Nostro, Farida Sarangi, +11 authors G. Keller
  • Biology, Medicine
  • Development
  • 2011 (First Publication: 1 March 2011)
  • The generation of insulin-producing β-cells from human pluripotent stem cells is dependent on efficient endoderm induction and appropriate patterning and specification of this germ layer to aExpand
  • Raewyn M. Seaberg, Simon R. Smukler, +5 authors Derek van der Kooy
  • Medicine, Biology
  • Nature Biotechnology
  • 2004 (First Publication: 22 August 2004)
  • The clonal isolation of putative adult pancreatic precursors has been an elusive goal of researchers seeking to develop cell replacement strategies for diabetes. We report the clonal identificationExpand
  • Tamara J. Nicolson, Elisa A. Bellomo, +30 authors Guy A. Rutter
  • Medicine, Biology
  • Diabetes
  • 2009 (First Publication: 19 June 2009)
  • OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding theExpand
  • Guoxin Kang, Jamie William Joseph, +6 authors George G. Holz
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2003 (First Publication: 7 March 2003)
  • The second messenger cAMP exerts powerful stimulatory effects on Ca2+ signaling and insulin secretion in pancreatic β-cells. Previous studies of β-cells focused on protein kinase A (PKA) as aExpand
  • Peter E Light, Jocelyn E. Manning Fox, Michael J. Riedel, Michael B Wheeler
  • Biology, Medicine
  • Molecular endocrinology
  • 2002 (First Publication: 1 September 2002)
  • Glucagon-like peptide-1 (GLP-1) elicits a glucose-dependent insulin secretory effect via elevation of cAMP and activation of protein kinase A (PKA). GLP-1-mediated closure of ATP-sensitive potassiumExpand