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Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid beta (A beta) peptide, the major constituent of AD plaques. We expressed human APP751 containing these mutations in the brains of transgenic mice. Two transgenic mouse lines develop pathological features(More)
The beta-amyloid precursor protein (APP) carries mutations in codons 717 or 670/671, which cosegregate with familial forms of Alzheimer's disease (AD). As an initial step to study the related pathogenetic mechanisms in vivo we have generated transgenic mice expressing APP with these mutations. Several neuron-specific promoters were used to drive expression(More)
BACKGROUND Enhancing the upward translocation of heavy metals such as Zn from root to shoot through genetic engineering has potential for biofortification and phytoremediation. This study examined the contribution of the heavy metal-transporting ATPase, AtHMA4, to the shoot ionomic profile of soil-grown plants, and investigated the importance of the(More)
Since its founding, NASA has been dedicated to the advancement of aeronautics and space science. The NASA Scientific and Technical Information (STI) Program Office plays a key part in helping NASA maintain this important role. The NASA STI Program Office is operated by Langley Research Center, the lead center for NASA's scientific and technical information.(More)
OBJECTIVE This article aims to describe the process of implementation of the 2004 Indigenous Mental Health Royal Australian and New Zealand College of Psychiatrists (RANZCP) Training By-Laws within Victoria. CONCLUSIONS It is likely that the challenges of ensuring access to this training experience, within the Victorian RANZCP Training Program, have been(More)
OBJECTIVES The aim of this paper is to document the processes towards ensuring that all psychiatrists in training in Victoria have appropriate Indigenous mental health experience and training. CONCLUSIONS This paper describes the process of implementation of the 2004 Indigenous Mental Health Royal Australian and New Zealand College of Psychiatrists(More)
OBJECTIVE The aim of this paper is to describe 'The Tofts', a private psychiatric hospital in the reigns of Edward VII and George V. CONCLUSIONS An addendum to the history of psychiatry, in Australia is the conduct or treatment for the mentally ill in private hospitals during the nineteenth and early twentieth centuries. This paper describes one such(More)
Any opinions, findings, and conclusions or recommendations expressed in this volume are those of the author(s) and do not necessarily reflect the views of the National Aeronautics and Space Administration. Material in this volume may be copied without restraint for library, abstract service, education, or personal research purposes; however, republication(More)