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Detailed in situ analyses reveal overlapping expression of gsc and Xbra in the early Spemann's organizer. Coexpression is lost during gastrulation suggesting an interaction between these genes. Ectopic expression of gsc ventrally suppresses endogenous Xbra expression and transcription from Xbra promoter reporter gene constructs. Suppression is mediated, at(More)
Every year, influenza virus infection causes significant mortality and morbidity in human populations. Although egg-based inactivated viral vaccines are available, their effectiveness depends on the correct prediction of the circulating viral strains and is limited by the time constraint of the manufacturing process. Recombinant subunit vaccines are easier(More)
Autoantibodies directed against the skeletal muscle acetylcholine receptor (AChR) play a critical role in the pathogenesis of the autoimmune disease, myasthenia gravis (MG). The pathogenic importance of anti-AChR antibodies is substantiated clinically by the often dramatic clinical improvement that follows removal of circulating antibodies utilizing(More)
Mark Rehse form ViroCyt opened his talk with the question of how many viruses are in the ocean as a way of introducing the topic of virus quantification. As it turns out, there is an estimated 100 million viruses in a milliliter of your average sea water, which—if you do the math—means that there are 1.3 £ 10 viruses in all of the Earth’s oceans. Add to(More)
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