Michael Ante

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House mice (Mus musculus) produce a variable number of major urinary proteins (MUPs), and studies suggest that each individual produces a unique MUP profile that provides a distinctive odor signature controlling individual and kin recognition. This 'barcode hypothesis' requires that MUP urinary profiles show high individual variability within populations(More)
Reconstruction of protein-protein interaction or metabolic networks based on expression data often involves in silico predictions, while on the other hand, there are unspecific networks of in vivo interactions derived from knowledge bases. We analyze networks designed to come as close as possible to data measured in vivo, both with respect to the set of(More)
We have systematically analyzed various topological patterns comprising 1, 2 or 3 nodes in the mammalian metabolic, signal transduction and transcription networks: These patterns were analyzed with regard to their frequency and statistical over-representation in each network, as well as to their topological significance for the coherence of the networks.(More)
Spike-In RNA variants (SIRVs) enable for the first time the validation of RNA sequencing workflows using external isoform transcript controls. 69 transcripts, derived from seven human model genes, cover the eukaryotic transcriptome complexity of start-and end-site variations, alternative splicing, overlapping genes, and antisense transcription in a(More)
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