Michael Althaus

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NMDA-receptors are a major target in the prevention and treatment of hyperalgesic pain states in neuropathic pain. However, previous studies revealed equivocal results depending on study design and efficacy parameters. We tested the analgesic (generalized reduction of generation and processing of nociceptive signalling) and anti-hyperalgesic (prevention of(More)
BACKGROUND Neramexane is a new substance that exhibits antagonistic properties at α9α10 cholinergic nicotinic receptors and N-methyl-D-aspartate receptors, suggesting potential efficacy in the treatment of tinnitus. METHODS A total of 431 outpatients with moderate to severe subjective tinnitus (onset 3-18 months before screening) were assigned randomly to(More)
A rapid and sensitive assay for the determination of dihydroergocryptine (DHEC) in human plasma and urine samples with dihydroergotamine (DHET) as the internal standard was developed. The procedure employs on-line sample preparation using an extraction pre-column and an octadecylsilylsilica (ODS) analytical column. After centrifugation human plasma or urine(More)
Markus Suckfuell (markus.suckfuell@med.uni-muenchen.de) Michael Althaus (michael.althaus@merz.de) Barbara Ellers-Lenz (Barbara.Ellers-Lenz@merz.de) Alexander Gebauer (Alexander.Gebauer@merz.de) Roman Goertelmeyer (Roman.Goertelmeyer@merz.de) Pawel J. Jastreboff (pjastre@emory.edu) Hans J. Moebius (hj.moebius@gmx.net) Tanja Rosenberg(More)
In a double-blind, randomized, comparative study, 101 atients subjected to natural events like insect bites or solar erythemas were treated locally with either dimethindene (DIM) gel (n=49) or placebo (PLA) gel (n=52). Mosquito bites were the most frequent incidents. Efficacy assessment was based on the speed of disappearance of itching. When only the first(More)
AIM This study was carried out to evaluate the pharmacokinetic profile of alpha-dihydroergocryptine (CAS 14271-05-7, DHEC, Almirid) in plasma and urine in patients with moderately to severely impaired renal function (creatinine clearance < 30 ml.min-1.1.73 m-2), following administration of single oral doses. METHODS This was an open, nonrandomized trial.(More)
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