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Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.
- H. Mori, Tyler C. Prestwich, +7 authors O. Macdougald
- Biology, Medicine
- The Journal of clinical investigation
- 2 July 2012
Preadipocytes secrete several WNT family proteins that act through autocrine/paracrine mechanisms to inhibit adipogenesis. The activity of WNT ligands is often decreased by secreted frizzled-related… Expand
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion
Changes in cellular oxygen tension play important roles in physiological processes including development and pathological processes such as tumor promotion. The cellular adaptations to sustained… Expand
TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response
Despite advances in our understanding of protein kinase regulation in the DNA damage response, the mechanism that controls protein phosphatase activity in this pathway is unclear. Unlike kinases, the… Expand
Digoxin Targets Central Carbon Metabolism and Remodels the Tumor Microenvironment
Cancer therapies targeting metabolism have been limited due to toxicity, compound availability, and efficacy. Therefore, strategies for targeting tumor-specific vulnerabilities remain highly desired.… Expand