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- Michael A. Laflamme, Kent Y Chen, +16 authors Charles E Murry
- Nature Biotechnology
- 2007
Cardiomyocytes derived from human embryonic stem (hES) cells potentially offer large numbers of cells to facilitate repair of the infarcted heart. However, this approach has been limited by… (More)
- James J.H. Chong, Xiulan Yang, +22 authors Charles E Murry
- Nature
- 2014
Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by providing human cardiomyocytes to support heart regeneration. Studies of human… (More)
- Michael A. Laflamme, Charles E Murry
- Nature
- 2011
Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a… (More)
- Michael A. Laflamme, Joseph Gold, +5 authors Charles E Murry
- The American journal of pathology
- 2005
Human embryonic stem cells (hESCs) offer the opportunity to replenish cells lost in the postinfarct heart. We explored whether human myocardium could be generated in rat hearts by injecting… (More)
- Scott D. Lundy, W Zhu, Michael Regnier, Michael A. Laflamme
- Stem cells and development
- 2013
Despite preclinical studies demonstrating the functional benefit of transplanting human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the ability of these immature… (More)
- Yuji Shiba, Sarah Fernandes, +19 authors Michael A. Laflamme
- Nature
- 2012
Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts, but two critical issues related to… (More)
- Michael A. Laflamme, Charles E Murry
- Nature Biotechnology
- 2005
Cell-based cardiac repair offers the promise of rebuilding the injured heart from its component parts. Work began with committed cells such as skeletal myoblasts, but recently the field has expanded… (More)
- Jeannette Nussbaum, Elina Minami, +7 authors Charles E Murry
- FASEB journal : official publication of the…
- 2007
Embryonic stem (ES) cells are promising for cardiac repair, but directing their differentiation toward cardiomyocytes remains challenging. We investigated whether the heart guides ES cells toward… (More)
Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies
- Gang Wang, Megan Laura McCain, +25 authors William T. Pu
- Nature Medicine
- 2014
Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial roles in cardiac development and disease. Here, we combined patient-derived and genetically engineered induced… (More)
- Lauran R. Madden, Derek J. Mortisen, +7 authors Buddy D. Ratner
- Proceedings of the National Academy of Sciences…
- 2010
We demonstrate here a cardiac tissue-engineering strategy addressing multicellular organization, integration into host myocardium, and directional cues to reconstruct the functional architecture of… (More)