Michael A. Wortley

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BACKGROUND Recent studies have suggested that the long-acting muscarinic receptor antagonist tiotropium, a drug widely prescribed for its bronchodilator activity in patients with chronic obstructive pulmonary disease and asthma, improves symptoms and attenuates cough in preclinical and clinical tussive agent challenge studies. The mechanism by which(More)
BACKGROUND Sensory nerves innervating the airways play an important role in regulating various cardiopulmonary functions, maintaining homeostasis under healthy conditions and contributing to pathophysiology in disease states. Hypo-osmotic solutions elicit sensory reflexes, including cough, and are a potent stimulus for airway narrowing in asthmatic(More)
OBJECTIVE To investigate biomechanical (kinematic) differences between 2 ankle brace testing protocols: landing on an inverted surface (IS) and inversion drop on an inversion platform. DESIGN Five trials in each of 4 dynamic movement conditions were performed: inversion drop and drop landing from 0.45 m onto an IS without and with an ankle brace. A(More)
BACKGROUND Theophylline has been used in the treatment of asthma and chronic obstructive pulmonary disease for more than 80 years. In addition to bronchodilator and anti-inflammatory activity, clinical studies have suggested that theophylline acts as an antitussive agent. Cough is the most frequent reason for consultation with a family doctor, and treatment(More)
STUDY DESIGN Controlled laboratory study. OBJECTIVES To examine effectiveness of an ankle brace with a subtalar locking system in restricting ankle inversion during passive and dynamic movements. BACKGROUND Semirigid ankle braces are considered more effective in restricting ankle inversion than other types of brace, but a semirigid brace with a subtalar(More)
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