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The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding assays, a fully biocompatible in vitro model was developed which can accurately mimic a wide range of physiological flow conditions on a thumbnail-format cell-chip. This(More)
— In this paper we investigated the applicability of commonly used white-balancing algorithms to restoring faded photographic colour slides. We have used three sets of synthetic data that simulated colour damage in Kodak Ektachrome slides, as well as three sets of real digitized faded Kodak Ektachrome slides. We have restored all the data sets using nine(More)
Changes of the functionality of the blood-brain barrier (BBB) have been reported in the context of several brain related diseases such as multiple sclerosis, epilepsy, Alzheimer's disease and stroke. Several publications indicated the presence and functionality of the NMDA receptor (NMDAR) at the brain endothelium and a possible involvement of the NMDAR in(More)
The largest single feature on a mammogram is the skin-air interface, or breast contour. Extraction of the breast contour is useful for a number of reasons. Foremost it allows the search for abnormalities to be limited to the region of the breast without undue influence from the background of the mammogram. Segmentation of the breast-region from the(More)
BACKGROUND Chondroprotective agents (CPA) such as glucosamine, curcumin and diacerein represent potential remedies for the management of osteoarthritis and several studies have been performed on their effects in-vitro and in-vivo. For the investigation of chondroprotective action on chondrocyte gene expression, quantitative real-time RT-PCR is the method of(More)
Intratympanic glucocorticoid therapy aims to reduce the side effects associated with systemic long-time therapy of inner ear diseases or traumata after cochlear implantation. For that purpose, thermoreversible hydrogels being fluid at room temperature but solid at body temperature are known to be appropriate drug delivery systems. In this work, the two key(More)
One of the caveats of the process of designing image processing algorithms is that they are often tested on insignificant numbers of images. This paper discusses the influence of mammogram databases on the performance evaluation of algorithms. We hope to demonstrate that the use of extensive collections of mammograms with varied characteristics to assess(More)
The scanning and computerized processing of images had its birth in 1956 at the National Bureau of Standards (NBS, now National Institute of Standards and Technology (NIST)) [1]. Image enhancement algorithms were some of the first to be developed [2]. Half a century later, literally thousands of image processing algorithms have been published. Some of these(More)