Michael A. Walters

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In Africa, Epstein-Barr virus (EBV) is associated with Burkitt lymphoma. We measured levels of EBV DNA in saliva and buffy coats from 233 asymptomatic Ugandan children with sickle cell disease and their mothers by quantitative real-time polymerase chain reaction. EBV DNA was detected in saliva from 90% of the children (median [interquartile range [IQR]](More)
The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms a hexamer composed of two AAA domains (D1 and D2) that form two stacked rings and an N-terminal domain that binds numerous cofactor proteins. The interplay(More)
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas)(More)
With de novo rational drug design, scientists can rapidly generate a very large number of potentially biologically active probes. However, many of them may be synthetically infeasible and, therefore, of limited value to drug developers. On the other hand, most of the tools for synthetic accessibility evaluation are very slow and can process only a few(More)
OBJECTIVE We investigated changes in hematologic and biochemical parameters associated with human T lymphotropic virus type 1 (HTLV-1) infection, antibody titer, and provirus load. Additionally, on a subset of participants, we assessed the epidemiologic relationship of HTLV-1 with Strongyloides stercoralis. METHODS Among volunteer blood donors in Jamaica,(More)
The organ cultivation of lung tissue can be used to study the differences in the age reaction to blastomogenic action and to screen and test new carcinogenic agents, especially water-soluble substances. Comparison of the results of transplacental and immediate introduction of some blastomogenic compounds into organ cultures of the lung can provide new(More)
The number of academic drug discovery centres has grown considerably in recent years, providing new opportunities to couple the curiosity-driven research culture in academia with rigorous preclinical drug discovery practices used in industry. To fully realize the potential of these opportunities, it is important that academic researchers understand the(More)
OBJECTIVE To identify immunologic and virologic predictors of AIDS-associated Kaposi's sarcoma (KS). DESIGN Nested case-control analysis of KS risk in a cohort of 132 HIV-infected homosexual men in New York and Washington, DC, USA. METHODS For each KS case, we selected two HIV-infected controls, matched for CD4 cell count and Kaposi's sarcoma-associated(More)