Michael A. Singer

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OBJECTIVE To evaluate the long-term safety and efficacy of multiple intravitreal ranibizumab injections (Lucentis, Genentech, Inc., South San Francisco, CA) administered at the investigator's discretion in patients with choroidal neovascularization secondary to age-related macular degeneration. DESIGN An open-label, multicenter, extension study. (More)
The classical uniformization theorem provides a complete translation dictionary for the etymologically unrelated languages of complex 1-manifolds and constant curvature Riemannian 2-manifolds. In higher dimensions, there are a number of natural ways in which one might try to generalize this remarkable theorem; unfortunately, these various potential(More)
PURPOSE To evaluate Ozurdex (dexamethasone intravitreal implant [DEX implant]; Allergan, Inc, Irvine, CA) 0.7 mg combined with laser photocoagulation compared with laser alone for treatment of diffuse diabetic macular edema (DME). DESIGN Randomized, controlled, multicenter, double-masked, parallel-group, 12-month trial. PARTICIPANTS Two hundred(More)
OBJECTIVE We discuss and evaluate surgical strategies and results in 42 patients with a variety of tumors involving the anterior and anterolateral foramen magnum and present factors affecting the degree of resection and patient outcomes. We describe our surgical techniques for resection of these tumors via the lateral approach, including consideration for(More)
Low vision devices in the past have been mainly extraocular. There are now four new devices in different stages of development and implementation that are currently available. Three of them, the Implantable Miniature Telescope (IMT, VisionCare Ophthalmic Technologies, Saratoga, CA), Intraocular Lens for Visually Impaired People (IOL-VIP, IOL-VIP System,(More)
Complement is present in ocular fluids, but the molecular mechanism(s) restricting its activation to exogenous targets and not to autologous ocular cells are currently unknown. To clarify how this control is achieved, monoclonal antibody (mAb)-based techniques were used to examine the eye, the lacrimal gland, and ocular fluids for the decay-accelerating(More)
A 48-year-old woman with a previous a liver transplant and a cataract extraction developed a necrotizing retinochoroiditis in her right eye. Vitreous and serum cultures failed to yield a causative organism. As the retinochoroiditis progressed, visual acuity worsened to the point of no light perception, and the eye became blind and painful. An enucleation(More)
PURPOSE To establish the extent of the peripheral retinal vasculature in normal eyes using ultra-widefield (UWF) fluorescein angiography. DESIGN Prospective, observational study. PARTICIPANTS Fifty-nine eyes of 31 normal subjects, stratified by age, with no evidence of ocular disease in either eye by history and ophthalmoscopic examination. METHODS(More)
OBJECTIVE To demonstrate a surgical technique for visualization and removal of visually significant posterior capsule opacification (PCO) in a patient with a telescope prosthesis for end-stage age-related macular degeneration, in what is to our knowledge the first reported case of visually significant PCO associated with the use of this device. METHODS A(More)